IMMUNOPHENOTYPIC AND GENOTYPIC ANALYSIS IN CUTANEOUS LYMPHOID HYPERPLASIAS

被引:42
作者
HAMMER, E [1 ]
SANGUEZA, O [1 ]
SUWANJINDAR, P [1 ]
WHITE, CR [1 ]
BRAZIEL, RM [1 ]
机构
[1] OREGON HLTH SCI UNIV, DEPT PATHOL, UHS 19, 3181 SAM JACKSON PK RD, PORTLAND, OR 97201 USA
关键词
D O I
10.1016/0190-9622(93)70063-Y
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background. The clinical utility of immunophenotyping and Southern blot analysis in the evaluation of patients with cutaneous lymphoid hyperplasia (CLH) is controversial. Objective. Our purpose was to determine whether adjunctive immunophenotyping and Southern blot analysis are of diagnostic and prognostic value in patients with CLH. Methods: Immunophenotyping was performed on skin biopsy specimens from 26 patients with a routine histologic diagnosis of CLH. Southern blot analysis for immunoglobulin (Ig) gene rearrangements was done on 13 of 26 cases. Results. Twenty-four of 26 patients had polyclonal CLH on immunophenotyping; 2 of 26 had monoclonal lymphoma. Two of 11 patients with polyclonal CLH studied by Southern blot analysis had clonal Ig gene rearrangements. In both, lymphoma developed within 1 to 6 years; comparison of CLH and malignant lymphoma demonstrated overlapping and different clonal bands. Two additional patients with polyclonal CLH developed lymphoma. No clonal gene rearrangements were detected in the CLH or lymphoma from one; the other was not studied. Conclusion: Immunophenotyping will identify some patients with lymphoma with nondiagnostic histologic features. Southern blot analysis will predict some patients with polyclonal CLH in whom malignant lymphoma will develop and who may benefit from definitive therapy.
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页码:426 / 433
页数:8
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