TRANSACTIVATION AND TRANSFORMATION BY MYB ARE NEGATIVELY REGULATED BY A LEUCINE-ZIPPER STRUCTURE

被引：120

作者：

KANEIISHII, C

MACMILLAN, EM

NOMURA, T

SARAI, A

RAMSAY, RG

AIMOTO, S

ISHII, S

GONDA, TJ

机构：

[1] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,TSUKUBA,IBARAKI 305,JAPAN

[2] INST MED & VET SCI,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA

[3] OSAKA UNIV,INST PROT RES,SUITA,OSAKA 565,JAPAN

[4] ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES,TUMOR BIOL BRANCH,PARKVILLE,VIC 3050,AUSTRALIA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 07期

关键词：

ONCOGENE; DNA-BINDING PROTEIN; NEGATIVE REGULATORY DOMAIN; POINT MUTANTS; INHIBITORS;

D O I：

10.1073/pnas.89.7.3088

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The negative regulatory domain of the c-myb protooncogene product (c-Myb) normally represses transcriptional activation by c-Myb. We show here that a leucine-zipper structure is a component of the negative regulatory domain, because its disruption markedly increases both the transactivating and transforming capacities of c-Myb. We also demonstrate that this leucine-zipper structure can interact with cellular proteins. Our results suggest that an inhibitor that suppresses transactivation binds to c-Myb through the leucine zipper and that c-Myb can be oncogenically activated by missense mutation.

引用

页码：3088 / 3092

页数：5

共 30 条

[1] IP-1 - A DOMINANT INHIBITOR OF FOS/JUN WHOSE ACTIVITY IS MODULATED BY PHOSPHORYLATION
AUWERX, J
SASSONECORSI, P
[J]. CELL, 1991, 64 (05) : 983 - 993
[2] CONTROL OF C-JUN ACTIVITY BY INTERACTION OF A CELL-SPECIFIC INHIBITOR WITH REGULATORY DOMAIN-DELTA - DIFFERENCES BETWEEN V-JUN AND C-JUN
BAICHWAL, VR
TJIAN, R
[J]. CELL, 1990, 63 (04) : 815 - 825
[3] VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY
BIEDENKAPP, H
BORGMEYER, U
SIPPEL, AE
KLEMPNAUER, KH
[J]. NATURE, 1988, 335 (6193) : 835 - 837
[4] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI
DIGNAM, JD
LEBOVITZ, RM
ROEDER, RG
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (05) : 1475 - 1489
[5] EISENBERG G, 1984, J MOL BIOL, V17, P125
[6] PARALLEL ASSOCIATION OF FOS AND JUN LEUCINE ZIPPERS JUXTAPOSES DNA-BINDING DOMAINS
GENTZ, R
RAUSCHER, FJ
ABATE, C
CURRAN, T
[J]. SCIENCE, 1989, 243 (4899) : 1695 - 1699
[7] ACTIVATION OF C-MYB BY CARBOXY-TERMINAL TRUNCATION - RELATIONSHIP TO TRANSFORMATION OF MURINE HEMATOPOIETIC-CELLS INVITRO
GONDA, TJ
BUCKMASTER, C
RAMSAY, RG
[J]. EMBO JOURNAL, 1989, 8 (06) : 1777 - 1783
[8] NUCLEOTIDE-SEQUENCE OF CDNA CLONES OF THE MURINE MYB PROTOONCOGENE
GONDA, TJ
GOUGH, NM
DUNN, AR
DEBLAQUIERE, J
[J]. EMBO JOURNAL, 1985, 4 (08) : 2003 - 2008
[9] HU YL, 1991, ONCOGENE, V6, P1549
[10] A-TYPE POTASSIUM CHANNELS EXPRESSED FROM SHAKER LOCUS CDNA
IVERSON, LE
TANOUYE, MA
LESTER, HA
DAVIDSON, N
RUDY, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) : 5723 - 5727

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