INHIBITORY EFFECTS OF ERGOSTEROL ISOLATED FROM THE EDIBLE MUSHROOM HYPSIZIGUS-MARMOREUS ON TPA-INDUCED INFLAMMATORY EAR EDEMA AND TUMOR PROMOTION IN MICE

被引:79
作者
YASUKAWA, K
AOKI, T
TAKIDO, M
IKEKAWA, T
SAITO, H
MATSUZAWA, T
机构
[1] NATL CANC CTR, RES INST, CHUO KU, TOKYO, TOKYO 104, JAPAN
[2] NAGANO PREFECTURAL RES INST RURAL IND, SUZAKA, NAGANO 382, JAPAN
关键词
EDIBLE MUSHROOM; HYPSIZIGUS MARMOREUS; ERGOSTEROL; TPA-INDUCED TUMOR PROMOTION; ANTITUMOR PROMOTION;
D O I
10.1002/ptr.2650080103
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
An antitumour-promoting activity in two-stage carcinogenesis, was found in the methanol and ethyl acetate extracts of the Japanese edible mushroom 'Buna-shimeji', Hypsizigus marmoreus (Tricholomataceae). From the active fractions of the extracts, two sterols, ergosterol and ergosterol peroxide, were isolated. The isolates showed inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced ear inflammation in mice, and ergosterol markedly inhibited tumour promotion in a two-stage carcinogenesis experiment. These sterols may be useful in developing an effective method of cancer prevention.
引用
收藏
页码:10 / 13
页数:4
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