INHIBITORY EFFECTS OF ERGOSTEROL ISOLATED FROM THE EDIBLE MUSHROOM HYPSIZIGUS-MARMOREUS ON TPA-INDUCED INFLAMMATORY EAR EDEMA AND TUMOR PROMOTION IN MICE

被引：79

作者：

YASUKAWA, K

AOKI, T

TAKIDO, M

IKEKAWA, T

SAITO, H

MATSUZAWA, T

机构：

[1] NATL CANC CTR, RES INST, CHUO KU, TOKYO, TOKYO 104, JAPAN

[2] NAGANO PREFECTURAL RES INST RURAL IND, SUZAKA, NAGANO 382, JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 01期

关键词：

EDIBLE MUSHROOM; HYPSIZIGUS MARMOREUS; ERGOSTEROL; TPA-INDUCED TUMOR PROMOTION; ANTITUMOR PROMOTION;

D O I：

10.1002/ptr.2650080103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An antitumour-promoting activity in two-stage carcinogenesis, was found in the methanol and ethyl acetate extracts of the Japanese edible mushroom 'Buna-shimeji', Hypsizigus marmoreus (Tricholomataceae). From the active fractions of the extracts, two sterols, ergosterol and ergosterol peroxide, were isolated. The isolates showed inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced ear inflammation in mice, and ergosterol markedly inhibited tumour promotion in a two-stage carcinogenesis experiment. These sterols may be useful in developing an effective method of cancer prevention.

引用

页码：10 / 13

页数：4

共 18 条

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