INHIBITORY EFFECT OF TANNIN IN GREEN TEA ON THE PROLIFERATION OF MESANGIAL CELLS

被引：27

作者：

YOKOZAWA, T

OURA, H

HATTORI, M

IWANO, M

DOHI, K

SAKANAKA, S

KIM, M

机构：

[1] NARA MED UNIV,DEPT INTERNAL MED 1,KASHIHARA,NARA 634,JAPAN

[2] TAIYO KAGAKU CO LTD,CENT RES LABS,YOKKAICHI,MIE,JAPAN

来源：

NEPHRON | 1993年 / 65卷 / 04期

关键词：

MESANGIAL CELL; PROLIFERATION; GREEN TEA TANNIN; (-)-EPIGALLOCATECHIN 3-O-GALLATE; (-)-EPICATECHIN 3-O-GALLATE;

D O I：

10.1159/000187570

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of green tea tannin on the proliferation of mesangial cells was determined in terms of [H-3]thymidine uptake. When green tea tannin was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells markedly. In particular, (-)-epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, exerted an inhibitory effect at a relatively low concentration, suggesting a direct corroboration of the renal effects.

引用

页码：596 / 600

页数：5

共 24 条

[1] MESANGIAL FUNCTION AND GLOMERULAR SCLEROSIS IN RATS WITH AMINONUCLEOSIDE NEPHROSIS [J].