EFFECTS OF ISOTONIC SALINE LOADING ON RENAL TUBULAR AND NEUROGENIC DOPAMINE RELEASE IN CONSCIOUS RABBITS

被引：8

作者：

AKAMA, H

NOSHIRO, T

SANO, N

WATANABE, T

TRIGG, L

KOTSONIS, P

MAJEWSKI, H

MCGRATH, BP

MIURA, Y

ABE, K

机构：

[1] MONASH UNIV,MONASH MED CTR,DEPT MED,CLAYTON,VIC 3168,AUSTRALIA

[2] MONASH MED CTR,PRINCE HENRYS INST MED RES,CLAYTON,VIC,AUSTRALIA

[3] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 2,SENDAI,MIYAGI 980,JAPAN

[4] TOHOKU UNIV,GRAD SCH INFORMAT SCI,DEPT INFORMAT & PATHOPHYSIOL,SENDAI,MIYAGI,JAPAN

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 6-7期

关键词：

DOPAMINE EXCRETION; DOPAMINE SPILLOVER; KIDNEY; NORADRENALINE SPILLOVER;

D O I：

10.1111/j.1440-1681.1995.tb02047.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. This study was designed to investigate the effects of isotonic saline loading on renal tubular and neurogenic dopamine (DA) in conscious rabbits. 2. Isotonic saline loading did not affect mean arterial pressure, heart rate or renal blood flow but markedly increased urine volume, sodium excretion and DA excretion. 3. Renal DA spillover was not affected by venous emptying, while renal noradrenaline (NA) spillover tended to decrease during saline loading. The ratio of % renal DA spillover to % renal NA spillover increased to 2.3 +/- .0.6 (P < 0.05) 3 h after saline loading. 4. Isotonic saline loading increased renal tubular DA production but had little effect on neurogenic DA release.

引用

页码：469 / 471

页数：3

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