THE PHARMACOKINETICS OF A NEW RADIOSENSITIZER, RO-03-8799 IN HUMANS

被引：17

作者：

ALLEN, JG

DISCHE, S

LENOXSMITH, I

MALCOLM, SL

SAUNDERS, MI

机构：

[1] ROCHE PROD LTD,DEPT DRUG METAB,POB 8,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[2] MT VERNON HOSP,CTR REG RADIOTHERAPY,MARIE CURIE RES WING ONCOL,NORTHWOOD HA6 2RN,MIDDX,ENGLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1984年 / 27卷 / 04期

关键词：

D O I：

10.1007/BF00549599

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：483 / 489

页数：7

共 12 条

[1] ELECTRON-AFFINIC SENSITIZATION .7. CORRELATION BETWEEN STRUCTURES ONE-ELECTRON REDUCTION POTENTIALS, AND EFFICIENCIES OF NITROIMIDAZOLES AS HYPOXIC CELL RADIOSENSITIZERS [J].

ADAMS, GE ;

FLOCKHART, IR ;

SMITHEN, CE ;

STRATFORD, IJ ;

WARDMAN, P ;

WATTS, ME .

RADIATION RESEARCH, 1976, 67 (01) :9-20

[2]

BIRCHER J, 1976, CLIN PHARMACOL THER, V20, P484

[3] CLINICAL TESTING OF RADIOSENSITIZER RO 07-0582 - EXPERIENCE WITH MULTIPLE DOSES [J].

DISCHE, S ;

SAUNDERS, MI ;

LEE, ME ;

ADAMS, GE ;

FLOCKHART, IR .

BRITISH JOURNAL OF CANCER, 1977, 35 (05) :567-579

[4]

FRANCIS RJ, 1984, COMP PROGR BIOMED

[5] ESTIMATION OF CREATININE CLEARANCE FROM SERUM CREATININE CONCENTRATION - REVIEW [J].

LOTT, RS ;

HAYTON, WL .

DRUG INTELLIGENCE & CLINICAL PHARMACY, 1978, 12 (03) :140-150

[6] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF THE NEW HYPOXIC CELL RADIOSENSITIZER, RO 03-8799, IN BIOLOGICAL SAMPLES [J].

MALCOLM, SL ;

LEE, A ;

GROVES, JK .

JOURNAL OF CHROMATOGRAPHY, 1983, 273 (02) :327-333

[7] RADIOSENSITIZATION BY MISONIDAZOLE (RO 07-0582) - IMPORTANCE OF TIMING AND TUMOR CONCENTRATION OF SENSITIZER [J].

MCNALLY, NJ ;

DENEKAMP, J ;

SHELDON, P ;

FLOCKHART, IR ;

STEWART, FA .

RADIATION RESEARCH, 1978, 73 (03) :568-580

[8] THE RADIOSENSITIZER RO 03-8799 AND THE CONCENTRATIONS WHICH MAY BE ACHIEVED IN HUMAN-TUMORS - A PRELIMINARY-STUDY [J].

SAUNDERS, MI ;

DISCHE, S ;

FERMONT, D ;

BISHOP, A ;

LENOXSMITH, I ;

ALLEN, JG ;

MALCOLM, SL .

BRITISH JOURNAL OF CANCER, 1982, 46 (05) :706-710

[9]

SCHWADE JG, 1981, CANCER CLIN TRIALS, V4, P33

[10]

Smithen C., 1980, RAD SENSITIZERS THEI, P22

← 1 2 →