ALPHA-INTERFERON TREATMENT IN CHINESE PATIENTS WITH CHRONIC HEPATITIS-B

被引:13
作者
LOK, ASF [1 ]
LAI, CL [1 ]
WU, PC [1 ]
LAU, JYN [1 ]
LEUNG, EKY [1 ]
WONG, LSK [1 ]
FUNG, YL [1 ]
机构
[1] UNIV HONG KONG,QUEEN MARY HOSP,DEPT PATHOL,HONG KONG,HONG KONG
关键词
D O I
10.1016/0168-8278(90)90177-S
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
alpha-Interferon has been shown to be the most promising antiviral agent in the treatment of chronic hepatitis B virus infection in Caucasian patients. The experience with recombinant interferon alfa-2a and alfa-2b in four randomized controlled trials in Chinese adults and children is reviewed here. alpha-Interferon alone has little long-term benefit in the treatment of Chinese patients with chronic hepatitis B virus infection, especially in patients who have normal or near normal serum aminotransferase levels. The response in patients with elevated aminotransferase levels appears to be better. The poor antiviral response in patients with normal aminotransferase levels is probably due to immunological tolerance to HBV induced by exposure to the virus in early life. Prednisone pretreatment does not seem to have any additional benefit to using interferon alone in these patients, while the effect in patients with elevated aminotransferase levels remains to be proven.
引用
收藏
页码:S121 / S125
页数:5
相关论文
共 19 条
  • [1] ALEXANDER GJM, 1987, LANCET, V2, P66
  • [2] BEASLEY RP, 1982, HEPATOLOGY, V2, P215
  • [3] THE ETIOLOGY OF ACUTE HEPATITIS IN TAIWAN - ACUTE HEPATITIS SUPERIMPOSED ON HBSAG CARRIER STATE AS THE MAIN ETIOLOGY OF ACUTE HEPATITIS IN AREAS WITH HIGH HBSAG CARRIER RATE
    CHU, CM
    SHEEN, IS
    LIAW, YF
    [J]. INFECTION, 1988, 16 (04) : 233 - 237
  • [4] RECOMBINANT LEUKOCYTE INTERFERON TREATMENT OF CHRONIC HEPATITIS-B
    DUSHEIKO, G
    DIBISCEGLIE, A
    BOWYER, S
    SACHS, E
    RITCHIE, M
    SCHOUB, B
    KEW, M
    [J]. HEPATOLOGY, 1985, 5 (04) : 556 - 560
  • [5] RANDOMIZED, CONTROLLED TRIAL OF RECOMBINANT HUMAN ALPHA-INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-B
    HOOFNAGLE, JH
    PETERS, M
    MULLEN, KD
    JONES, DB
    RUSTGI, V
    DIBISCEGLIE, A
    HALLAHAN, C
    PARK, Y
    MESCHIEVITZ, C
    JONES, EA
    [J]. GASTROENTEROLOGY, 1988, 95 (05) : 1318 - 1325
  • [6] LAI C L, 1989, Gastroenterology, V96, pA618
  • [7] LAI CL, 1987, LANCET, V2, P877
  • [8] LOK A S F, 1989, Gastroenterology, V96, pA623
  • [9] A LONGITUDINAL FOLLOW-UP OF ASYMPTOMATIC HEPATITIS-B SURFACE ANTIGEN-POSITIVE CHINESE-CHILDREN
    LOK, ASF
    LAI, CL
    [J]. HEPATOLOGY, 1988, 8 (05) : 1130 - 1133
  • [10] A RANDOMIZED STUDY OF THE EFFECTS OF ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE (SHORT OR LONG COURSES) AND LYMPHOBLASTOID INTERFERON ON HEPATITIS-B VIRUS-REPLICATION
    LOK, ASF
    NOVICK, DM
    KARAYIANNIS, P
    DUNK, AA
    SHERLOCK, S
    THOMAS, HC
    [J]. HEPATOLOGY, 1985, 5 (06) : 1132 - 1138