HOW TO MAKE A GLYCOINOSITOL PHOSPHOLIPID ANCHOR

被引：47

作者：

TARTAKOFF, AM

SINGH, N

机构：

[1] A. M. Tartakoff and N. Singh are, the Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 11期

关键词：

D O I：

10.1016/0968-0004(92)90491-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Essentially all eukaryotic cells express proteins on their surface that are anchored by a glycoinositol phospholipid. This anchor moiety may endow such proteins with unusual properties. The definition of the biosynthetic path that constructs these anchors is now in its final stages. Mutations that interrupt this path are, remarkably, compatible with survival of cells in culture, but are associated with at least one human disease.

引用

页码：470 / 473

页数：4

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