MULTIPLE EXTRACELLULAR SIGNALS GOVERN THE PRODUCTION OF A MORPHOGENETIC PROTEIN INVOLVED IN AERIAL MYCELIUM FORMATION BY STREPTOMYCES-COELICOLOR

被引:125
作者
WILLEY, J
SCHWEDOCK, J
LOSICK, R
机构
[1] Biological Laboratories, Harvard University, Cambridge
关键词
STREPTOMYCES-COELICOLOR; MORPHOGENETIC PROTEIN; AERIAL MYCELIUM FORMATION; MORPHOLOGICAL DIFFERENTIATION;
D O I
10.1101/gad.7.5.895
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The formation of an aerial mycelium by the filamentous bacterium Streptomyces coelicolor is determined in part by a small morphogenetic protein called SapB. A collection of representative bald (bld) mutants, which are blocked in aerial mycelium formation, are all defective in the production of this protein and regain the capacity to undergo morphological differentiation when SapB is supplied exogenously. We now report that most of the bld mutants are rescued for SapB production and aerial mycelium formation when grown near certain other bld mutants. Extracellular complementation experiments of this kind indicate that morphological differentiation is governed by a hierarchical cascade of at least four kinds of intercellular signals. At least one such signal is present in conditioned medium. It is resistant to boiling and protease treatment, and it remains effective even when diluted up to eightfold in fresh medium.
引用
收藏
页码:895 / 903
页数:9
相关论文
共 25 条
[1]   SECONDARY METABOLITES AS CHEMICAL SIGNALS FOR CELLULAR-DIFFERENTIATION [J].
BEPPU, T .
GENE, 1992, 115 (1-2) :159-165
[2]  
BIRO S, 1980, EUR J BIOCHEM, V103, P359, DOI 10.1111/j.1432-1033.1980.tb04322.x
[4]  
CHATER KF, 1989, REGULATION OF PROCARYOTIC DEVELOPMENT, P277
[5]   THE DEVELOPMENTAL FATE OF S-COELICOLOR HYPHAE DEPENDS UPON A GENE-PRODUCT HOMOLOGOUS WITH THE MOTILITY SIGMA-FACTOR OF B-SUBTILIS [J].
CHATER, KF ;
BRUTON, CJ ;
PLASKITT, KA ;
BUTTNER, MJ ;
MENDEZ, C ;
HELMANN, JD .
CELL, 1989, 59 (01) :133-143
[6]   MORPHOLOGICAL AND GENETIC MAPPING STUDY OF WHITE COLONY MUTANTS OF STREPTOMYCES-COELICOLOR [J].
CHATER, KF .
JOURNAL OF GENERAL MICROBIOLOGY, 1972, 72 (AUG) :9-&
[7]   THE EXPRESSION OF STREPTOMYCES AND ESCHERICHIA-COLI DRUG-RESISTANCE DETERMINANTS CLONED INTO THE STREPTOMYCES PHAGE PHI-C31 [J].
CHATER, KF ;
BRUTON, CJ ;
KING, AA ;
SUAREZ, JE .
GENE, 1982, 19 (01) :21-32
[8]  
Dale Kaiser, 1989, GENETICS BACTERIAL D, P243
[9]   PROMOTER DETERMINING THE TIMING AND SPATIAL LOCALIZATION OF TRANSCRIPTION OF A CLONED STREPTOMYCES-COELICOLOR GENE ENCODING A SPORE-ASSOCIATED POLYPEPTIDE [J].
GUIJARRO, J ;
SANTAMARIA, R ;
SCHAUER, A ;
LOSICK, R .
JOURNAL OF BACTERIOLOGY, 1988, 170 (04) :1895-1901
[10]   SYNERGISM BETWEEN MORPHOGENETIC MUTANTS OF MYXOCOCCUS-XANTHUS [J].
HAGEN, DC ;
BRETSCHER, AP ;
KAISER, D .
DEVELOPMENTAL BIOLOGY, 1978, 64 (02) :284-296