MOLECULAR-WEIGHT CHANGES IN POLYMER EROSION

被引：27

作者：

DEMANUELE, A ^{[1
]}

HILL, J ^{[1
]}

TAMADA, JA ^{[1
]}

DOMB, AJ ^{[1
]}

LANGER, R ^{[1
]}

机构：

[1] MIT,DEPT CHEM ENGN,77 MASSACHUSETTS AVE,E25-342,CAMBRIDGE,MA 02139

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 10期

关键词：

DRUG DELIVERY SYSTEM; ERODIBLE POLYMERS; POLYANHYDRIDES; INDUCTION PERIOD; MOLECULAR WEIGHT;

D O I：

10.1023/A:1015801216466

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the erosion rate is relatively slow. The length of this period depends on the initial molecular weight of the polymer. The induction period may be characterized as a time during which a rapid decrease in polymer molecular weight occurs, the end of this period correlating with the time required for the polymer molecular weight to decrease to below a value of approximately 5000 (MW).

引用

页码：1279 / 1283

页数：5

共 19 条

[1] Chasin M, 1990, BIODEGRADABLE POLYM, P43
[2] CHASIN M, 1988, BIOPHARM MANUF, V1, P33
[3] AN INVESTIGATION OF THE EFFECTS OF ULTRASOUND ON DEGRADABLE POLYANHYDRIDE MATRICES
DEMANUELE, A
KOST, J
HILL, JL
LANGER, R
[J]. MACROMOLECULES, 1992, 25 (02) : 511 - 515
[4] DOI Y, 1990, MACROMOLECULES, V23, P26, DOI 10.1021/ma00203a006
[5] SOLID-STATE AND SOLUTION STABILITY OF POLY(ANHYDRIDES) AND POLY(ESTERS)
DOMB, AJ
LANGER, R
[J]. MACROMOLECULES, 1989, 22 (05) : 2117 - 2122
[6] FUKUZAKI H, 1990, MAKROMOL CHEM, V191, P731
[7] HOLLAND S J, 1986, Journal of Controlled Release, V4, P155, DOI 10.1016/0168-3659(86)90001-5
[8] POLYMERS FOR BIODEGRADABLE MEDICAL DEVICES .2. HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS - HYDROLYTIC DEGRADATION STUDIES
HOLLAND, SJ
JOLLY, AM
YASIN, M
TIGHE, BJ
[J]. BIOMATERIALS, 1987, 8 (04) : 289 - 295
[9] POLYMERS FOR BIODEGRADABLE MEDICAL DEVICES .7. HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS - DEGRADATION OF COPOLYMERS AND THEIR BLENDS WITH POLYSACCHARIDES UNDER INVITRO PHYSIOLOGICAL CONDITIONS
HOLLAND, SJ
YASIN, M
TIGHE, BJ
[J]. BIOMATERIALS, 1990, 11 (03) : 206 - 215
[10] HUTCHINSON FG, 1989, BIODEGRADABLE POLYM, P111

← 1 2 →