TOTAL STEREOSPECIFIC SYNTHESIS OF ALL CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID (EPA)

被引：16

作者：

VIALA, J

SANDRI, J

机构：

[1] Laboratoire de Synthese Organique Associe au CNRS. Universite d'Aix-Marseille III -

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

ALL CIS-EICOSAPENTAENOIC ACID; EPA; CIS-WITTIG REACTION; OZONOLYSIS;

D O I：

10.1016/S0040-4039(00)61227-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total stereospecific synthesis of EPA has been performed by a sequence of ozonolysis, selective reduction and Wittig reactions which affords the cis-skipped olefinic system. Versatile Compound 4, readily prepared from dihydro anisole, allowed us to prepare the skipped dienic synthon 2 in high yield.

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页码：4897 / 4900

页数：4

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