AN INTERACTION OF BETA-AMYLOID WITH ALUMINUM INVITRO

被引：126

作者：

EXLEY, C ^{[1
]}

PRICE, NC ^{[1
]}

KELLY, SM ^{[1
]}

BIRCHALL, JD ^{[1
]}

机构：

[1] UNIV STIRLING, DEPT BIOL & MOLEC SCI, STIRLING FK9 4LA, SCOTLAND

来源：

FEBS LETTERS | 1993年 / 324卷 / 03期

关键词：

ALUMINUM (BIOLOGY); BETA-AMYLOID PROTEIN; ALZHEIMERS DISEASE; CIRCULAR DICHROISM SPECTROSCOPY;

D O I：

10.1016/0014-5793(93)80137-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, AbetaP(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.

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页码：293 / 295

页数：3

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