LOCALIZATION OF 2 MOUSE GENES ENCODING THE PROTEIN-TYROSINE KINASE RECEPTOR-RELATED PROTEIN RYK

被引：5

作者：

GOUGH, NM

RAKAR, S

HOVENS, CM

WILKS, A

机构：

[1] ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES,PARKVILLE,VIC 3050,AUSTRALIA

[2] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA

来源：

MAMMALIAN GENOME | 1995年 / 6卷 / 04期

关键词：

D O I：

10.1007/BF00352411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have mapped the gene encoding the murine RYK growth factor receptor protein tyrosine kinase by genetic linkage analysis with recombinant inbred strains of mouse. Two distinct Ryk loci (Ryk-1 and Ryk-2) were identified. Ryk-1 mapped to Chromosome (Chr) 9, whereas Ryk-2 mapped to Chr 12. A similar arrangement of RYK-related loci was previously determined in the human. Synteny has already been established between murine Chr 9 in the region of Ryk-1, and human chromosome 3q11-12, the location of the human RYK-1 gene. However, the Ryk-2/RYK-2 loci on murine Chr 12 and human Chr 17p13.3 define a new region of synteny.

引用

页码：255 / 256

页数：2

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