BIOCHEMICAL GENETICS OF METHYLGLYOXAL DEHYDROGENASES IN THE LABORATORY RAT (RATTUS-NORVEGICUS)

被引：9

作者：

BENDER, K

SEIBERT, RT

WIENKER, TF

KREN, V

PRAVENEC, M

BISSBORT, S

机构：

[1] CHARLES UNIV,BIOL USTAV,CR-12800 PRAGUE,CZECH REPUBLIC

[2] ACAD SCI CZECH REPUBL,INST PHYSIOL,CR-14220 PRAGUE 4,CZECH REPUBLIC

来源：

BIOCHEMICAL GENETICS | 1994年 / 32卷 / 5-6期

关键词：

METHYLGLYOXAL; METHYLGLYOXAL DEHYDROGENASE LOCI 1; 2; 3; MGD1; POLYMORPHISM; HEART-SPECIFIC MGD3 EXPRESSION; GLYOXALASE I; RAT CHROMOSOME 13;

D O I：

10.1007/BF00554618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fired either allele Mgd1(a) or allele Mgd1(b). Codominant expression is observed in heterozygotes, providing evidence for a tetramer c enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.

引用

页码：147 / 154

页数：8

共 17 条

[1]

[Anonymous], 1976, HDB ENZYME ELECTROPH

[2]

BENDER K, 1985, TRANSPL P, V17, P1872

[3]

BENDER K, 1984, RAT NEWSLETT, V13, P10

[4] METHYLGLYOXAL-CATABOLIZING ENZYMES OF LEISHMANIA-DONOVANI PROMASTIGOTES [J].