Heat shock protein-based cancer vaccines and related thoughts on immunogenicity of human tumors

被引：40

作者：

Blachere, NE

Srivastava, PK

机构：

[1] Department of Biological Sciences, Fordham University, Bronx

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 06期

关键词：

cytotoxic T cells; pan-valency; unique antigens; shared antigens; melanoma;

D O I：

10.1016/1044-579X(95)90004-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock proteins (HSPs) are associated in vivo with the entire repertoire Of peptides (antigenic and otherwise) generated within that cell. Immunization with such non-covalent HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T-cell epitopes for any given cancer or infectious agent.

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收藏

页码：349 / 355

页数：7

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