RHABDOMYOLYSIS AND ACUTE-RENAL-FAILURE DURING HIGH-DOSE HALOPERIDOL THERAPY

被引：12

作者：

MARSH, SJ ^{[1
]}

DOLSON, GM ^{[1
]}

机构：

[1] VET ADM MED CTR,RENAL SECT,HOUSTON,TX 77030

来源：

RENAL FAILURE | 1995年 / 17卷 / 04期

关键词：

ACUTE RENAL FAILURE; HALOPERIDOL; NEUROLEPTIC MALIGNANT SYNDROME; RHABDOMYOLYSIS;

D O I：

10.3109/08860229509037611

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Severe adverse reactions to neuroleptic medications are not uncommon and include the neuroleptic malignant syndrome, rhabdomyolysis, and acute renal failure. The neuroleptic malignant syndrome consists of hyperthermia, diaphoresis, tachycardia, tachypnea, abnormal blood pressure, alteration of consciousness, and extrapyramidal rigidity. Rhabdomyolysis-which might be due to hyperthermia, muscle: rigidity, and/or metabolic changes in skeletal muscle function-results in acute renal failure. We report a patient with rhabdomyolysis and acute renal failure that developed after large doses of haloperidol were given, but without muscle rigidity or hyperthermia. This patient's presentation illustrates that high-dose haloperidol therapy might cause rhabdomyolysis and acute renal failure without significant rigidity or hyperthermia.

引用

页码：475 / 478

页数：4

共 8 条

[1] Levenson J.L., Neuroleptic malignant syndrome, Am J Psychiatry, 142, pp. 1137-1145, (1985)
[2] Eiser A.R., Neff M.S., Slifken R.F., Acute myoglobinuric renal failure: a consequence of the neuroleptic malignant syndrome, Arch Intern Med, 142, pp. 601-603, (1982)
[3] Gabow A.G., Kaehny W.D., Kelleher S.P., The spectrum of rhabdomyolysis, Medicine, 61, pp. 141-152, (1982)
[4] Schulze V.E., Rhabdomyolysis as a cause of acute renal failure, Postgrad Med, 72, pp. 145-158, (1982)
[5] Lazarus A., Mann S.C., Caroff S.N., The neuroleptic malignant syndrome, The Neuroleptic Malignant Syndrome and Related Conditions, pp. 1-56, (1989)
[6] Anderson S.A., Weinshenk K., Peripheral neuropathy as a component of the neuroleptic malignant syndrome, Am J Med, 82, pp. 169-170, (1987)
[7] Pope H.G., Keck P.E., McElroy S.L., Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital, Am J Psychiatry, 143, pp. 1227-1233, (1986)
[8] Addonzio G., Susman V.L., Roth S.D., Symptoms of neuroleptic malignant syndrome in 82 consecutive inpatients, Am J Psychiatry, 143, pp. 1587-1590, (1986)

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