Chemistry and neurochemistry of the kynurenine pathway of tryptophan metabolism

被引：84

作者：

Botting, NP

机构：

[1] School of Chemistry, University of St. Andrews, St. Andrews

来源：

CHEMICAL SOCIETY REVIEWS | 1995年 / 24卷 / 06期

关键词：

D O I：

10.1039/cs9952400401

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The kynurenine pathway of tryptophan metabolism is currently of considerable interest due to biological activities of various kynurenine metabolites. The most important appears to be quinolinic acid, which has been implicated as an etiological factor in a range of neurodegenerative diseases. The enzymes on the pathway are also mechanistically interesting and have some unusual features. This review describes the pathway, discusses the mechanisms of the enzymes involved and examines the strategies that have been employed for inhibitor design.

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页码：401 / &

页数：13

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