DETERMINATION OF VITAMIN-D3 AND VITAMIN-D2 IN MULTIVITAMIN TABLETS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY

被引：9

作者：

ADACHI, T

NISHIO, M

YUNOKI, N

ITO, Y

HAYASHI, H

机构：

[1] Department of Pharmaceutics, Research Center, Taisho Pharmaceutical Co., Ltd, Yoshinocho, Ohmiya

来源：

ANALYTICAL SCIENCES | 1994年 / 10卷 / 03期

关键词：

LIQUID CHROMATOGRAPHY ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY; VITAMIN-D3; VITAMIN-D2; FLOW INJECTION ANALYSIS ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY;

D O I：

10.2116/analsci.10.457

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry was used to determine vitamin D3 and its analogs. Vitamin D3 and its analogs were separated on a reversed phase ODS column. The eluent was fed into the atmospheric pressure ionization interface and vitamins were then quantitated in the selected ion monitoring mode. The detection limit of vitamin D3 and its analogs were ca.0.5 ng (on-column) at a signal-to-noise ratio of 2. This method was used to determine vitamin D3 and D2 in multi-vitamin tablets. The flow injection mode was also effective for the determination of VD3 in multi-vitamin tablets.

引用

页码：457 / 460

页数：4