EFFECTS OF INTERLEUKIN-4 OR STEM-CELL FACTOR ON MAST-CELL MEDIATOR RELEASE AND CYTOKINE GENE-EXPRESSION

被引：6

作者：

COLEMAN, JW ^{[1
]}

BUCKLEY, MG ^{[1
]}

TAYLOR, AM ^{[1
]}

BANKS, EMS ^{[1
]}

WILLIAMS, CMM ^{[1
]}

HOLLIDAY, MR ^{[1
]}

THOMPSON, J ^{[1
]}

机构：

[1] GLAXO RES & DEV LTD,GREENFORD,MIDDX,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

基金：

英国惠康基金;

关键词：

MAST CELLS; STEM CELL FACTOR; MEDIATOR RELEASE; CYTOKINE GENES; INTERLEUKIN-4;

D O I：

10.1159/000236961

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene expression in the human HMC-1 mast cell line. SCF, but not IL-4, induced low levels of serotonin release from mouse or rat have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.

引用

页码：154 / 155

页数：2

共 7 条

[1]

BUCKLEY MG, IN PRESS IMMUNOLOGY

[2]

COLEMAN JW, 1990, IMMUNOLOGY, V69, P150

[3] INTERFERON-GAMMA INHIBITS SEROTONIN RELEASE FROM MOUSE PERITONEAL MAST-CELLS [J].