LUPIN ALKALOIDS FROM TERATOGENIC AND NON-TERATOGENIC LUPINS .3. IDENTIFICATION OF ANAGYRINE AS PROBABLE TERATOGEN BY FEEDING TRIALS

被引：73

作者：

KEELER, RF ^{[1
]}

机构：

[1] USDA, ARS, POISONOUS PLANT RES LAB, WESTERN REG, LOGAN, UT 84321 USA

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1976年 / 1卷 / 06期

关键词：

D O I：

10.1080/15287397609529391

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Alkaloidal extracts from teratogenic lupins produced congenital deformities in calves typical of crooked calf disease when the extracts were administered to pregnant cows during the susceptible gestational period. These data and previous epidemiologic studies suggest that 1 of the 4 alkaloids in the preparation, anagyrine, is the responsible teratogen. Severity of the malformations was directly related to the level of anagyrine present in the preparations administered.

引用

页码：887 / 898

页数：12

共 8 条

[1] LUPIN ALKALOIDS FROM TERATOGENIC AND NON-TERATOGENIC LUPINS .4. CONCENTRATION OF TOTAL ALKALOIDS, INDIVIDUAL MAJOR ALKALOIDS, AND TERATOGEN ANAGYRINE AS A FUNCTION OF PLANT PART AND STAGE OF GROWTH AND THEIR RELATIONSHIP TO CROOKED CALF DISEASE [J].

KEELER, RF ;

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SHUPE, JL .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1976, 1 (06) :899-908

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[4] LUPIN ALKALOIDS FROM TERATOGENIC AND NONTERATOGENIC LUPINS .1. CORRELATION OF CROOKED CALF DISEASE INCIDENCE WITH ALKALOID DISTRIBUTION DETERMINED BY GAS-CHROMATOGRAPHY [J].

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[5] LUPIN ALKALOIDS FROM TERATOGENIC AND NONTERATOGENIC LUPINS .2. IDENTIFICATION OF MAJOR ALKALOIDS BY TANDEM GAS CHROMATOGRAPHY MASS SPECTROMETRY IN PLANTS PRODUCING CROOKED CALF DISEASE [J].

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