SYNTHESIS, REACTIVITY, AND BIOACTIVITY OF AVERMECTIN-B1-3,4-OXIDE

被引:17
作者
BLIZZARD, TA
MROZIK, H
PREISER, FA
FISHER, MH
机构
关键词
D O I
10.1016/S0040-4039(00)97779-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Avermectin B1-3,4-oxide (2) has been synthesized from avermectin B1 (1). While epoxide 2 is comparable to avermectin B1 in bioactivity, opening of the epoxide leads to derivatives which are substantially less bioactive. © 1990.
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页码:4965 / 4968
页数:4
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