EFFECT OF THE AQUEOUS EXTRACT AND SAPONIN FRACTION FROM THE FLOWERS OF VERBASCUM-THAPSIFORME ON PROTEIN-BIOSYNTHESIS IN A RAT-LIVER RIBOSOMAL SYSTEM

被引：12

作者：

PASZKIEWICZGADEK, A ^{[1
]}

GROCHOWSKA, K ^{[1
]}

GALASINSKI, W ^{[1
]}

机构：

[1] MED ACAD BIALYSTOK,INST CHEM,DEPT GEN & ORGAN CHEM,PL-15230 BIALYSTOK 8,POLAND

来源：

PHYTOTHERAPY RESEARCH | 1990年 / 4卷 / 05期

关键词：

aqueous extract; inhibition of protein biosynthesis; saponins; Verbascum thapsiforme;

D O I：

10.1002/ptr.2650040504

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of fractions isolated from the aqueous extract of Verbascum flowers on protein biosynthesis was studied. A strong inhibitory effect of the aqueous extract on protein biosynthesis was demonstrated in isolated rat liver ribosomes. The saponin fraction was shown to be responsible for this activity and it was compared to commercial glycyrrhizic acid and its aglycon as the standard drungs. It was found that these compounds strongly inhibited the incorporation of [14C]leucine into proteins in vitro and that the target site for inhibition was the ribosome fraction from rat liver cells. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：177 / 181

页数：5

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