DOSE-RESPONSE OF CRYPTOSPORIDIUM-PARVUM IN OUTBRED NEONATAL CD-1 MICE

被引：70

作者：

FINCH, GR

DANIELS, CW

BLACK, EK

SCHAEFER, FW

BELOSEVIC, M

机构：

[1] UNIV ALBERTA,DEPT ZOOL,EDMONTON T6G 2E9,ALBERTA,CANADA

[2] UNIV ALBERTA,DEPT IMMUNOL,EDMONTON T6G 2E9,ALBERTA,CANADA

[3] US EPA,ENVIRONM MONITORING SYST LAB,OFF RES & DEV,CINCINNATI,OH 45268

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1993年 / 59卷 / 11期

关键词：

D O I：

10.1128/AEM.59.11.3661-3665.1993

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.

引用

页码：3661 / 3665

页数：5

共 24 条

[21]

Ungar B. L. P., 1990, Cryptosporidiosis of man and animals., P59

[22]

WAKELIN D, 1985, Parasitology Today, V1, P17, DOI 10.1016/0169-4758(85)90101-2

[23] ENTERIC COCCIDIOSIS AMONG PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].