ARRIVACINS, NOVEL PSEUDOGUAIANOLIDE ESTERS WITH POTENT ANGIOTENSIN-II BINDING-ACTIVITY FROM AMBROSIA-PSILOSTACHYA

被引：15

作者：

CHEN, YL

BEAN, MF

CHAMBERS, C

FRANCIS, T

HUDDLESTON, MJ

OFFEN, P

WESTLEY, JW

CARTE, BK

TIMMERMANN, BN

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT ANALYT,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406

[3] UNIV ARIZONA,COLL PHARM,DEPT PHARMACEUT SCI,TUCSON,AZ 85721

来源：

TETRAHEDRON | 1991年 / 47卷 / 27期

关键词：

D O I：

10.1016/S0040-4020(01)80953-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel pseudoguaianolide esters, arrivacins A (1) and B (2), have been isolated from the methylene chloride extract of Ambrosia psilostachya collected in Arrivaca Cienega, Arizona. The structures of the arrivacins, which are examples of sesquiterpene dimers formed from the condensation of two different pseudoguaianolide sesquiterpenes, were determined by analysis of the spectral data and chemical interconversion. Arrivacins A and B show potent binding to angiotensin II receptors in bovine adrenal membranes.

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页码：4869 / 4878

页数：10

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