SYNTHESIS AND EXCITATORY AMINO-ACID PHARMACOLOGY OF SOME NOVEL QUINOXALINEDIONES

被引：28

作者：

EPPERSON, JR

HEWAWASAM, P

MEANWELL, NA

BOISSARD, CG

GRIBKOFF, VK

POSTMUNSON, D

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80768-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and amino acid pharmacology of twelve N-substituted quinoxalinediones is reported. In particular, compounds 4a and 4b show significant antagonism at both the AMPA and glycine-site NMDA receptors. The functional antagonism of 4a has been demonstrated.

引用

页码：2801 / 2804

页数：4

共 24 条

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