CLONING OF A CDNA-ENCODING A PUTATIVE NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT OF THE HUMAN FILARIAL PARASITE ONCHOCERCA-VOLVULUS

被引：13

作者：

AJUH, PM ^{[1
]}

EGWANG, TG ^{[1
]}

机构：

[1] CTR INT RECH MED FRANCEVILLE,DEPT FILARIAL MOLEC BIOL,FRANCEVILLE,GABON

来源：

GENE | 1994年 / 144卷 / 01期

关键词：

RECOMBINANT DNA; BLINDNESS; ANTHELMINTICS; IVERMECTIN; PATHOGEN; NEUROTRANSMITTER;

D O I：

10.1016/0378-1119(94)90216-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A partial cDNA clone encoding a putative nicotinic acetylcholine receptor (ACHR) subunit of the human filarial parasite, Onchocerca volvulus, has been isolated and sequenced. A truncated open reading frame of 1308 bp capable of encoding 436 amino acids with a calculated M(r) of 51209 was identified. The absence of the double cysteine residues necessary for neurotransmitter binding indicates that the cloned ACHR is a non-alpha subunit.

引用

页码：127 / 129

页数：3

共 13 条

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