EFFECT OF AMINO-ACIDS ON RAPAMYCIN BIOSYNTHESIS BY STREPTOMYCES-HYGROSCOPICUS

被引：55

作者：

CHENG, YR ^{[1
]}

FANG, A ^{[1
]}

DEMAIN, AL ^{[1
]}

机构：

[1] MIT,FERMENTAT MICROBIOL LAB,CAMBRIDGE,MA 02139

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 1995年 / 43卷 / 06期

关键词：

D O I：

10.1007/BF00166931

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In a chemically defined medium containing aspartate, arginine and histidine to support good growth, addition of L-lysine stimulated rapamycin production by 150%. This was probably due to its conversion to pipecolic acid, a rapamycin precursor. Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.

引用

页码：1096 / 1098

页数：3

共 10 条

[1]

BRANA AF, 1988, NITROGEN SOURCE CONT, P99

[2]

CHENG YR, 1995, IN PRESS J IND MICRO

[3] EFFECT OF COBALT AND CYANOCOBALAMIN ON BIOSYNTHESIS OF A10255, A THIOPEPTIDE ANTIBIOTIC COMPLEX [J].