SUBSTRATE-DEPENDENT INHIBITION OF PROTEIN KINASE-C BY SPECIFIC INHIBITORS

被引：43

作者：

JUNCO, M ^{[1
]}

DIAZGUERRA, MJM ^{[1
]}

BOSCA, L ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC FARM,INST BIOQUIM,E-28040 MADRID,SPAIN

来源：

FEBS LETTERS | 1990年 / 263卷 / 01期

关键词：

H7; Phorbol ester; Protein kinase C; Staurosporine;

D O I：

10.1016/0014-5793(90)80731-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase C (PKC) and its proteolysis-derived protein kinase independent of Ca2+ and phospholipids (PKM), were purified from rat brain. By using histone HI and protamine as substrates, we assayed the effect of several inhibitors of PKC and PKM. The inhibition turned out to be dependent on both the nature of the kinase and the type of substrate assayed. These results may help to interpret the different responses elicited by PKC inhibitors in vivo. © 1990.

引用

页码：169 / 171

页数：3

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