INTERLEUKIN-1-BETA REGULATION OF ISLET AND THYROID AUTOIMMUNITY IN THE BB RAT

被引：25

作者：

VERTREES, S

WILSON, CA

UBUNGEN, R

WILSON, D

BASKIN, DG

TOIVOLA, B

JACOBS, C

BOIANI, N

BAKER, P

LERNMARK, A

机构：

[1] UNIV WASHINGTON, DEPT MED, RG-20, SEATTLE, WA 98195 USA

[2] UNIV WASHINGTON, DEPT BIOL STRUCT, SEATTLE, WA 98195 USA

[3] VET ADM MED CTR, DIV ENDOCRINOL, SEATTLE, WA 98108 USA

[4] IMMUNEX CORP, SEATTLE, WA 98101 USA

来源：

JOURNAL OF AUTOIMMUNITY | 1991年 / 4卷 / 05期

关键词：

D O I：

10.1016/0896-8411(91)90168-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1β protects diabetes-prone rats from IDDM, we conclude that IL-1β is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats. © 1991.

引用

页码：717 / 732

页数：16

共 35 条

[1] THE EFFECT OF IODIDE INGESTION ON THE DEVELOPMENT OF SPONTANEOUS LYMPHOCYTIC THYROIDITIS IN THE DIABETES-PRONE BB/W RAT [J].