EFFECTS OF GROWTH-HORMONE ON BODY-FAT IN ADULTS

被引:13
作者
GERTNER, JM
机构
关键词
GROWTH HORMONE; LIPOLYSIS; OBESITY; GROWTH HORMONE DEFICIENCY; ADIPOSE TISSUE;
D O I
10.1159/000183761
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The interactions between growth hormone (GH) and adipose tissue can be considered as a cycle: GH is lipolytic and acts to reduce and redistribute body fat; in turn, obesity is characterized by reduced GH output. The effects of GH on adipose tissue have been studied in obese, elderly and nonobese GH-deficient adults and children. In GH-deficient adults GH treatment appears to lead to net loss of fat tissue. However, evidence that GH promotes substantial weight loss in the obese is scanty. GH treatment trials in the elderly show significant increases in lean body mass and smaller decreases in fat mass. Data must be viewed with caution because of the methodological pitfalls inherent in measuring body composition and failure to induce net weight loss in the obese.
引用
收藏
页码:10 / 15
页数:6
相关论文
共 25 条
[1]   TREATMENT OF ADULTS WITH GROWTH-HORMONE (GH) DEFICIENCY WITH RECOMBINANT HUMAN GH [J].
BENGTSSON, BA ;
EDEN, S ;
LONN, L ;
KVIST, H ;
STOKLAND, A ;
LINDSTEDT, G ;
BOSAEUS, I ;
TOLLI, J ;
SJOSTROM, L ;
ISAKSSON, OGP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (02) :309-317
[2]   THE EFFECT OF GROWTH-HORMONE ADMINISTRATION IN GROWTH-HORMONE DEFICIENT ADULTS ON BONE, PROTEIN, CARBOHYDRATE AND LIPID HOMEOSTASIS, AS WELL AS ON BODY-COMPOSITION [J].
BINNERTS, A ;
SWART, GR ;
WILSON, JHP ;
HOOGERBRUGGE, N ;
POLS, HAP ;
BIRKENHAGER, JC ;
LAMBERTS, SWJ .
CLINICAL ENDOCRINOLOGY, 1992, 37 (01) :79-87
[3]   AN EVALUATION OF SEVENTY-FIVE PATIENTS WITH HYPOPITUITARISM BEGINNING IN CHILDHOOD [J].
BRASEL, JA ;
WRIGHT, JC ;
WILKINS, L ;
BLIZZARD, RM .
AMERICAN JOURNAL OF MEDICINE, 1965, 38 (04) :484-+
[4]   FREE FATTY-ACIDS BLOCK GROWTH-HORMONE (GH) RELEASING HORMONE-STIMULATED GH SECRETION IN MAN DIRECTLY AT THE PITUITARY [J].
CASANUEVA, FF ;
VILLANUEVA, L ;
DIEGUEZ, C ;
DIAZ, Y ;
CABRANES, JA ;
SZOKE, B ;
SCANLON, MF ;
SCHALLY, AV ;
FERNANDEZCRUZ, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (04) :634-642
[5]   GROWTH-HORMONE ADMINISTRATION CONSERVES LEAN BODY-MASS DURING DIETARY RESTRICTION IN OBESE SUBJECTS [J].
CLEMMONS, DR ;
SNYDER, DK ;
WILLIAMS, R ;
UNDERWOOD, LE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (05) :878-883
[6]   HUMAN GROWTH-HORMONE AND HUMAN AGING [J].
CORPAS, E ;
HARMAN, SM ;
BLACKMAN, MR .
ENDOCRINE REVIEWS, 1993, 14 (01) :20-39
[7]   INFLUENCE OF SUBSTRATE BACKGROUND ON PERIPHERAL TISSUE RESPONSES TO GROWTH-HORMONE [J].
FONG, Y ;
ROSENBAUM, M ;
HESSE, DG ;
TRACEY, KJ ;
GERTNER, J ;
LOWRY, SF .
JOURNAL OF SURGICAL RESEARCH, 1988, 44 (06) :702-708
[8]   SEPARATION OF EARLY AND LATE RESPONSES OF ADIPOSE-TISSUE TO GROWTH-HORMONE [J].
GOODMAN, HM .
ENDOCRINOLOGY, 1981, 109 (01) :120-129
[9]   EFFECTS OF HUMAN GROWTH HORMONE IN MAN [J].
HENNEMAN, PH ;
FORBES, AP ;
MOLDAWER, M ;
DEMPSEY, EF ;
CARROLL, EL .
JOURNAL OF CLINICAL INVESTIGATION, 1960, 39 (08) :1223-1238
[10]   THE EFFECT OF FREE FATTY-ACIDS ON GROWTH-HORMONE (GH)-RELEASING HORMONE-MEDIATED GH SECRETION IN MAN [J].
IMAKI, T ;
SHIBASAKI, T ;
SHIZUME, K ;
MASUDA, A ;
HOTTA, M ;
KIYOSAWA, Y ;
JIBIKI, K ;
DEMURA, H ;
TSUSHIMA, T ;
LING, N .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (02) :290-293