BENZOYLCELLULOSE DERIVATIVES AS CHIRAL STATIONARY PHASES FOR OPEN-TUBULAR COLUMN CHROMATOGRAPHY

被引：12

作者：

FRANCOTTE, E

GROLIMUND, K

JUVANCZ, Z

机构：

[1] CIBA GEIGY AG,CENT ANALYT DEPT,CH-4002 BASEL,SWITZERLAND

[2] CIBA GEIGY AG,PHARMACEUT RES,CH-4002 BASEL,SWITZERLAND

[3] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1025 BUDAPEST,HUNGARY

来源：

CHIRALITY | 1993年 / 5卷 / 04期

关键词：

ENANTIOMER; SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC); GAS CHROMATOGRAPHY (GC); RESOLUTION; POLYMER;

D O I：

10.1002/chir.530050408

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The application of cellulose-based stationary phases for chiral separations has been extended to open tubular column chromatography. Efficient columns were obtained by coating the capillaries with mixtures of chiral cellulose materials and conventional achiral stationary phases for gas chromatography. In this study, various siloxane and polyethylene glycol polymers were used as achiral components and mixed with different substituted benzoylcellulose derivatives as chiral components. Systematic investigations were carried out to determine the optimal ratio for the components of the stationary phase. Depending on the chromatographic mode-gas chromatography (GC) or supercritical fluid chromatography (SFC)-the stationary phases were found to behave differently. The applicability of the technique was demonstrated by the resolution of various racemic compounds. (C) 1993 Wiley-Liss, Inc.

引用

页码：232 / 237

页数：6

共 18 条

[1] BENZOYL CELLULOSE BEADS IN THE PURE POLYMERIC FORM AS A NEW POWERFUL SORBENT FOR THE CHROMATOGRAPHIC RESOLUTION OF RACEMATES [J].