MULTISUBSTRATE ADDUCTS AS POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE DEPENDENT METHYLASES - INHIBITION OF INDOLE N-METHYLTRANSFERASE BY (5'-DEOXYADENOSYL)[3-(3-INDOLYL)PROP-1-YL]METHYLSULFONIUM AND (5'-DEOXYADENOSYL)[4-(3-INDOLYL)BUT-1-YL]METHYLSULFONIUM SALTS

被引:17
作者
BENGHIAT, E [1 ]
CROOKS, PA [1 ]
机构
[1] UNIV KENTUCKY,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,LEXINGTON,KY 40536
关键词
D O I
10.1021/jm00364a021
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
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页码:1470 / 1477
页数:8
相关论文
共 42 条
[1]  
ANDERSEN KK, 1981, CHEM SULFONIUM GROUP, P229
[2]   SYNTHESIS AND EVALUATION OF SOME STABLE MULTISUBSTRATE ADDUCTS AS INHIBITORS OF CATECHOL O-METHYLTRANSFERASE [J].
ANDERSON, GL ;
BUSSOLOTTI, DL ;
COWARD, JK .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (11) :1271-1277
[3]  
AXELROD J, 1962, J PHARMACOL EXP THER, V138, P28
[4]   INDOLEAMINES IN BLOOD-PLASMA OF SCHIZOPHRENICS - CRITICAL STUDY WITH SENSITIVE AND SELECTIVE METHODS [J].
AXELSSON, S ;
NORDGREN, L .
LIFE SCIENCES, 1974, 14 (07) :1261-1270
[5]  
BENGHIAT E, 1982, SYNTHESIS, V12, P1033
[6]  
BOADER MR, 1976, BIOCH PHARM, V25, P2109
[7]  
BOADER MR, 1976, BRAIN RES, V114, P359
[8]   POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES .4. FURTHER MODIFICATIONS OF AMINO-ACID AND BASE PORTIONS OF S-ADENOSYL-L-HOMOCYSTEINE [J].
BORCHARDT, RT ;
HUBER, JA ;
WU, YS .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (09) :1094-1099
[9]  
BORCHARDT RT, 1976, BIOCH PHARM, V24, P1542
[10]  
CARPENTER WT, 1975, AM J PSYCHIAT, V132, P1067