EFFECTS OF D-AMPHETAMINE AND L-AMPHETAMINE ON DORSAL AND VENTRAL HYPOTHALAMIC SELF-STIMULATION IN 3 INBRED STRAINS OF MICE

被引:20
作者
CAZALA, P [1 ]
机构
[1] UNIV BORDEAUX 1, PSYCHOPHYSIOL LAB, F-33405 TALENCE, FRANCE
关键词
D O I
10.1016/0091-3057(76)90259-8
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of i.p. injections of increasing doses of d- and l-amphetamine on self-stimulation behavior in dorsal and ventral hypothalamic areas, were studied in BALB/c Orl, DBA/2 Orl, and C57BL/6 Orl inbred mice. Both isomers improved and disrupted self-stimulation as a function of the doses injected. The improvements obtained with d-amphetamine were higher than those obtained with l-amphetamine. The l isomer generally provoked the highest disruptions. The 3 strains presented various sensitivities to d-amphetamine, which improved self-stimulation 1st in BALB/c (0.25 and 0.50 mg/kg), then in DBA/2 (0.50 and 1.0 mg/kg) and finally in C57BL/6 (2.0, 4.0 and 8.0 mg/kg). The dorsal hypothalamic self-stimulation system presented a greater sensitivity to d-amphetamine than the ventral system; while the 2 reward systems reacted identically to l-amphetamine. The differential effects observed are set into relationship with neurochemical data concerning the central catecholaminergic mechanisms.
引用
收藏
页码:505 / 510
页数:6
相关论文
共 40 条
[1]   SELECTIVITY OF RELEASE OF NOREPINEPHRINE, DOPAMINE AND 5-HYDROXYTRYPTAMINE BY AMPHETAMINE IN VARIOUS REGIONS OF RAT-BRAIN [J].
AZZARO, AJ ;
RUTLEDGE, CO .
BIOCHEMICAL PHARMACOLOGY, 1973, 22 (22) :2801-2813
[2]   EFFECT OF MICROINJECTIONS OF AMPHETAMINE INTO NEOSTRIATUM AND NUCLEUS ACCUMBENS ON SELF-STIMULATION BEHAVIOR [J].
BROEKKAMP, CLE ;
PIJNENBURG, AJJ ;
COOLS, AR ;
VANROSSUM, JM .
PSYCHOPHARMACOLOGIA, 1975, 42 (02) :179-183
[3]  
BUNNEY BS, 1975, PSYCHOPHARMACOL COMM, V1, P177
[4]   DIFFERENTIAL EFFECTS OF AMPHETAMINE AND FOOD-DEPRIVATION ON SELF-STIMULATION OF LATERAL HYPOTHALAMUS AND MEDIAL FRONTAL CORTEX [J].
CAREY, RJ ;
GOODALL, E ;
LORENS, SA .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1975, 88 (01) :224-230
[5]   NOREPINEPHRINE - RELEASE FROM BRAIN BY D-AMPHETAMINE IN VIVO [J].
CARR, LA ;
MOORE, KE .
SCIENCE, 1969, 164 (3877) :322-&
[6]   SELF-STIMULATION THRESHOLDS AND DORSO-VENTRAL VARIATION IN LATERAL HYPOTHALAMUS IN MOUSE - EFFECTS OF FOOD AND WATER DEPRIVATION [J].
CAZALA, P ;
CAZALS, Y ;
CARDO, B .
PHYSIOLOGY & BEHAVIOR, 1976, 16 (02) :125-129
[7]   HYPOTHALAMIC SELF-STIMULATION IN 3 INBRED STRAINS OF MICE [J].
CAZALA, P ;
CAZALS, Y ;
CARDO, B .
BRAIN RESEARCH, 1974, 81 (01) :159-167
[8]  
CAZALA P, 1974, CR ACAD SCI D NAT, V278, P2657
[9]  
CHIUEH CC, 1975, J PHARMACOL EXP THER, V192, P642
[10]  
CHIUEH CC, 1974, J PHARMACOL EXP THER, V190, P100