HUMAN EXTRAVILLOUS TROPHOBLAST MHC CLASS-I EXPRESSION IS RESISTANT TO REGULATION BY INTERFERON-ALPHA

被引：15

作者：

CHUMBLEY, G

HAWLEY, S

CARTER, NP

LOKE, YW

机构：

[1] Division of Cellular and Genetic Pathology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, Tennis Court Road

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1991年 / 20卷 / 03期

基金：

英国医学研究理事会;

关键词：

TROPHOBLAST; MHC ANTIGEN; INTERFERON-ALPHA;

D O I：

10.1016/0165-0378(91)90053-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have shown that MHC Class I antigen expression by first trimester human extravillous trophoblast cells is resistant to upregulation by IFN-alpha while embryonic fibroblasts of the same gestational age are responsive. This is in contrast to our previous finding that IFN-gamma increases both Class I mRNA and surface expression in these trophoblast cells. It would appear that human trophoblast has differential susceptibility to the effects of the two classes of IFN.

引用

页码：289 / 296

页数：8

共 24 条

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