EFFECTS OF ISOXAZOLYL-NAPHTHOQUINONEIMINES ON GROWTH AND OXYGEN RADICAL PRODUCTION IN TRYPANOSOMA-CRUZI AND CRITHIDIA-FASCICULATA

被引:19
作者
DETARLOVSKY, MNS [1 ]
GOIJMAN, SG [1 ]
PORTELA, MPM [1 ]
STOPPANI, AOM [1 ]
机构
[1] UNIV BUENOS AIRES, SCH MED, DEPT BIOCHEM, RA-1121 BUENOS AIRES, ARGENTINA
来源
EXPERIENTIA | 1990年 / 46卷 / 05期
关键词
Crithidia fasciculata; DNA synthesis; growth inhibition; H[!sub]2[!/sub]O[!sub]2[!/sub] production; isoxazolyl-naphthoquinoneimines; Trypanosoma cruzi; {Mathematical expression} production;
D O I
10.1007/BF01954247
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Several 4-(aminomethylisoxazolyl)-1,2-naphthoquinones inhibited growth and DNA synthesis in Trypanosoma cruzi and stimulated O2 uptake and {Mathematical expression} generation by the parasite epimastigotes and their mitochondrial and microsomal membranes; these results support the idea that oxygen radicals play a role in quinone toxicity. Maximal effects on respiration and {Mathematical expression} generation were observed with antimycin-inhibited cells. Similar results as well as stimulation of H2O2 production were obtained with Crithidia fasciculata despite the presence of catalase in this organism. © 1990 Birkhäuser Verlag.
引用
收藏
页码:502 / 505
页数:4
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