EFFECTS OF ISOXAZOLYL-NAPHTHOQUINONEIMINES ON GROWTH AND OXYGEN RADICAL PRODUCTION IN TRYPANOSOMA-CRUZI AND CRITHIDIA-FASCICULATA

被引：19

作者：

DETARLOVSKY, MNS ^{[1
]}

GOIJMAN, SG ^{[1
]}

PORTELA, MPM ^{[1
]}

STOPPANI, AOM ^{[1
]}

机构：

[1] UNIV BUENOS AIRES, SCH MED, DEPT BIOCHEM, RA-1121 BUENOS AIRES, ARGENTINA

来源：

EXPERIENTIA | 1990年 / 46卷 / 05期

关键词：

Crithidia fasciculata; DNA synthesis; growth inhibition; H[!sub]2[!/sub]O[!sub]2[!/sub] production; isoxazolyl-naphthoquinoneimines; Trypanosoma cruzi; {Mathematical expression} production;

D O I：

10.1007/BF01954247

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several 4-(aminomethylisoxazolyl)-1,2-naphthoquinones inhibited growth and DNA synthesis in Trypanosoma cruzi and stimulated O2 uptake and {Mathematical expression} generation by the parasite epimastigotes and their mitochondrial and microsomal membranes; these results support the idea that oxygen radicals play a role in quinone toxicity. Maximal effects on respiration and {Mathematical expression} generation were observed with antimycin-inhibited cells. Similar results as well as stimulation of H2O2 production were obtained with Crithidia fasciculata despite the presence of catalase in this organism. © 1990 Birkhäuser Verlag.

引用

页码：502 / 505

页数：4

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