ANALYSIS OF WHOLE-ARM TRANSLOCATIONS IN MALIGNANT BLOOD-CELLS BY NONISOTOPIC IN SITU HYBRIDIZATION (WITH 1 COLOR PLATE)

被引：26

作者：

SPELEMAN, F

MANGELSCHOTS, K

VERCRUYSSEN, M

DALCIN, P

AVENTIN, A

OFFNER, F

LAUREYS, G

VANDENBERGHE, H

LEROY, J

机构：

[1] STATE UNIV GHENT HOSP,FACHBEREICH HEMATOL,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT HOSP,DEPT PEDIAT,B-9000 GHENT,BELGIUM

[3] UNIV INSTELLING ANTWERP,DEPT HUMAN GENET,B-2610 WILRIJK,BELGIUM

[4] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM

[5] UNIV BARCELONA,DEPT HEMATOL,BARCELONA 7,SPAIN

来源：

CYTOGENETICS AND CELL GENETICS | 1991年 / 56卷 / 01期

关键词：

D O I：

10.1159/000133036

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Whole-arm translocations in five leukemic patients were studied using nonisotopic in situ hybridization with alpha-satellite DNA and simple satellite chromosome-specific DNA probes to detect the target sequences. The results show that this technique provides additional information on the involvement of these DNA sequences in whole-arm translocations.

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页码：14 / &

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