CONFIRMATION OF TONSILLAR ANOMALIES IN IGA NEPHROPATHY - A MULTICENTER STUDY

被引：58

作者：

BENE, MC

DELIGNY, BH

KESSLER, M

FAURE, GC

机构：

[1] HOP CLEMENCEAU, SERV NEPHROL, CAEN, FRANCE

[2] CHU NANCY, NEPHROL SERV, F-54000 NANCY, FRANCE

来源：

NEPHRON | 1991年 / 58卷 / 04期

关键词：

IGA NEPHROPATHY; TONSILS; PLASMA CELLS; PATHOGENESIS;

D O I：

10.1159/000186474

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tonsillar abnormalities have previously been evidenced in IgA nephropathy (IgAN). We report the results of a systematic quantitative analysis of 303 tonsils obtained in 70 IgAN patients and 142 controls. IgG- and IgA-producing plasma cells, stained by immunofluorescence, were enumerated on serial sections of all samples. Both the percentage and number of IgA + cells were significantly increased in IgAN patients. This anomaly was also observed in age- or sex-matched subgroups of patients. Performed on a large series of individuals this study confirms the dysregulation of IgA production in the upper respiratory tract of IgAN patients.

引用

页码：425 / 428

页数：4

共 24 条

[1]

Alley C D, 1987, Adv Exp Med Biol, V216B, P1175

[2] ELEVATED PRODUCTION OF POLYMERIC AND MONOMERIC IGA1 BY THE BONE-MARROW IN IGA NEPHROPATHY [J].