MAPPING OF THE HUMAN TRANSCRIPTION FACTOR GABPA (E4TF1-60) GENE TO CHROMOSOME-21

被引：7

作者：

CHRAST, R

CHEN, HM

MORRIS, MA

ANTONARAKIS, SE

机构：

[1] UNIV GENEVA,SCH MED,DEPT GENET & MICROBIOL,GENES R US LAB HUMAN MOLEC GENET,CH-1211 GENEVA,SWITZERLAND

[2] CANTONAL HOSP,DIV MED GENET,GENEVA,SWITZERLAND

来源：

GENOMICS | 1995年 / 28卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1117

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exon trapping/amplification was used to clone portions of genes from human chromosome 21. One trapped sequence showed complete homology with nucleotide sequence D13318 of GenBank, which corresponds to the gene for human transcription factor E4TF1-60 (HGMW-approved nomenclature GABPA). We mapped this gene to human chromosome 21 by FISH, somatic cell hybrids, and hybridization to chromosome 21-specific YACs. The GABPA gene localizes to YACs 816B7 and 848G1 of the Chumakov et al. (Nature 359: 380, 1992) YAC contig, near the APP gene in 21q21-q22.1. This transcription factor, which is an ETS-related DNA-binding protein and forms heterodimers with other polypeptides, may contribute in a gene dosage-dependent manner to the phenotype of Down syndrome. (C) 1995 Academic Press, Inc.

引用

页码：119 / 122

页数：4

共 22 条

[1] HUMAN CHROMOSOME-21 - GENOME MAPPING AND EXPLORATION, CIRCA 1993 [J].

ANTONARAKIS, SE .

TRENDS IN GENETICS, 1993, 9 (04) :142-148

[2] SPECIFICITIES OF PROTEIN PROTEIN AND PROTEIN DNA INTERACTION OF GABP-ALPHA AND 2 NEWLY DEFINED ETS-RELATED PROTEINS [J].

BROWN, TA ;

MCKNIGHT, SL .

GENES & DEVELOPMENT, 1992, 6 (12B) :2502-2512

[3] EXON AMPLIFICATION - A STRATEGY TO ISOLATE MAMMALIAN GENES BASED ON RNA SPLICING [J].

BUCKLER, AJ ;

CHANG, DD ;

GRAW, SL ;

BROOK, JD ;

HABER, DA ;

SHARP, PA ;

HOUSMAN, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :4005-4009

[4]

Chen H. M., 1994, American Journal of Human Genetics, V55, pA255

[5] ISOLATION AND MAPPING OF HUMAN-CHROMOSOME-21 CDNA - PROGRESS IN CONSTRUCTING A CHROMOSOME-21 EXPRESSION MAP [J].

CHENG, JF ;

BOYARTCHUK, V ;

ZHU, YW .

GENOMICS, 1994, 23 (01) :75-84

[6] CONTINUUM OF OVERLAPPING CLONES SPANNING THE ENTIRE HUMAN CHROMOSOME-21Q [J].

CHUMAKOV, I ;

RIGAULT, P ;

GUILLOU, S ;

OUGEN, P ;

BILLAUT, A ;

GUASCONI, G ;

GERVY, P ;

LEGALL, I ;

SOULARUE, P ;

GRINAS, L ;

BOUGUELERET, L ;

BELLANNECHANTELOT, C ;

LACROIX, B ;

BARILLOT, E ;

GESNOUIN, P ;

POOK, S ;

VAYSSEIX, G ;

FRELAT, G ;

SCHMITZ, A ;

SAMBUCY, JL ;

BOSCH, A ;

ESTIVILL, X ;

WEISSENBACH, J ;

VIGNAL, A ;

RIETHMAN, H ;

COX, D ;

PATTERSON, D ;

GARDINER, K ;

HATTORI, M ;

SAKAKI, Y ;

ICHIKAWA, H ;

OHKI, M ;

LEPASLIER, D ;

HEILIG, R ;

ANTONARAKIS, S ;

COHEN, D .

NATURE, 1992, 359 (6394) :380-387

[7] ISOLATION OF GENES FROM COMPLEX SOURCES OF MAMMALIAN GENOMIC DNA USING EXON AMPLIFICATION [J].

CHURCH, DM ;

STOTLER, CJ ;

RUTTER, JL ;

MURRELL, JR ;

TROFATTER, JA ;

BUCKLER, AJ .

NATURE GENETICS, 1994, 6 (01) :98-105

[8]

Delabar Jean-Maurice, 1993, European Journal of Human Genetics, V1, P114

[9] MOLECULAR AND GENETIC-CHARACTERIZATION OF GABP-BETA [J].

DELABROUSSE, FC ;

BIRKENMEIER, EH ;

KING, DS ;

ROWE, LB ;

MCKNIGHT, SL .

GENES & DEVELOPMENT, 1994, 8 (15) :1853-1865

[10]

EPSTEIN CJ, 1988, ANNU REV GENET, V22, P51, DOI 10.1146/annurev.ge.22.120188.000411

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