RANDOMIZED STUDY OF PREINDUCTION CERVICAL RIPENING WITH SEQUENTIAL USE OF INTRAVAGINAL PROSTAGLANDIN E(2) GEL

被引:11
作者
CARLAN, SJ
DANNA, P
DURKEE, D
QUINSEY, C
LANARIS, B
机构
[1] Division of Medical Education, Department of Obstetrics and Gynecology, Orlando Regional Healthcare System, Orlando, FL
关键词
D O I
10.1016/0029-7844(94)00441-F
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate the safety and efficacy of serial frequent intravaginal prostaglandin (PG) E(2) gel applications in shortening the time required to achieve an inducible cervix. Methods: From May 1, 1993, through April 30, 1994, 101 pregnant women with medical indications for induction of labor and Bishop scores less than 7 were randomized to receive intravaginal 2.5 mg of PGE(2) gel every 6 hours or as often as every hour until the Bishop score was at least 7 or intervention was required. Results: The mean total number of PGE, gel applications was significantly different between the 1- and 6-hour groups, 6.5 and 4.4 PGE(2) applications, respectively. The mean time from PGE(2) application to delivery was similar, 42 and 45 hours, for the 1- and 6-hour groups, respectively. The intervention rate, occurrence of labor during ripening, and neonatal outcomes were also similar. Conclusion: Intravaginal application of 2.5 mg PGE(2) gel as frequently as every hour appears to be safe, but it does not decrease the time interval to induction or delivery, nor does it decrease the cesarean rate.
引用
收藏
页码:608 / 613
页数:6
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