WILMS-TUMOR LOCUS ON 11P13 DEFINED BY MULTIPLE CPG ISLAND-ASSOCIATED TRANSCRIPTS

被引：140

作者：

BONETTA, L

KUEHN, SE

HUANG, A

LAW, DJ

KALIKIN, LM

KOI, M

REEVE, AE

BROWNSTEIN, BH

YEGER, H

WILLIAMS, BRG

FEINBERG, AP

机构：

[1] UNIV MICHIGAN,SCH MED,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,DEPT HUMAN GENET,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,PROGRAM CELLULAR & MOLEC BIOL,ANN ARBOR,MI 48109

[5] HOSP SICK CHILDREN,RES INST,DEPT GENET,TORONTO M5G 1X8,ONTARIO,CANADA

[6] UNIV TORONTO,DEPT MICROBIOL,TORONTO M5S 1A1,ONTARIO,CANADA

[7] UNIV TORONTO,DEPT MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA

[8] UNIV OTAGO,DEPT BIOCHEM,DUNEDIN,NEW ZEALAND

[9] WASHINGTON UNIV,SCH MED,CTR GENET MED,ST LOUIS,MO 63110

[10] HOSP SICK CHILDREN,DEPT PATHOL,TORONTO M5G 1X8,ONTARIO,CANADA

[11] UNIV TORONTO,DEPT MICROBIOL & MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

SCIENCE | 1990年 / 250卷 / 4983期

关键词：

D O I：

10.1126/science.2173146

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wilms tumor is an embryonal kidney tumor involving complex pathology and genetics. The Wilms tumor locus on chromosome 11p13 is defined by the region of overlap of constitutional and tumor-associated deletions. Chromosome walking and yeast artificial chromosome (YAC) cloning were used to clone and map 850 kilobases of DNA. Nine CpG islands, constituting a "CpG island archipelago," were identified, including three islands that were not apparent by conventional pulsed-field mapping, and thus were at least partially methylated. Three distinct transcriptional units were found closely associated with a CpG island within the boundaries of a homozygous DNA deletion in a Wilms tumor.

引用

页码：994 / 997

页数：4

共 30 条

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