THE PRODUCTION OF PHOSPHATIDYLINOSITOL TRISPHOSPHATE IS STIMULATED BY THROMBIN IN HUMAN PLATELETS

被引:12
作者
NOLAN, RD [1 ]
LAPETINA, EG [1 ]
机构
[1] BURROUGHS WELLCOME CO,DIV CELL BIOL,RES TRIANGLE PK,NC 27709
关键词
D O I
10.1016/0006-291X(91)91448-L
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Untreated human platelets labeled to equilibrium with 32Pi contained undetectable levels of 3-phosphorylated phosphoinositides. Stimulation of platelets with thrombin for 5 min resulted in an enormous increase in the amount of phosphatidylinositol 3,4-bisphosphate (Nolan and Lapetina, J. Biol. Chem. 265, 2441-2445; 1990). We now report that the levels of phosphatidylinositol 3,4,5-trisphosphate are greatly elevated within 90 s of treatment of platelets with thrombin. Phosphatidylinositol 3,4,5-phosphate might have an important role in platelet aggregation. © 1991.
引用
收藏
页码:524 / 528
页数:5
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