EFFECT OF CIGARETTE-SMOKE INHALATION ON BENZO[A]PYRENE-INDUCED LUNG CARCINOGENESIS IN VITAMIN-A-DEFICIENCY IN THE RAT

被引：7

作者：

GUPTA, MP ^{[1
]}

KHANDUJA, KL ^{[1
]}

KOUL, IB ^{[1
]}

SHARMA, RR ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT BIOPHYS,CHANDIGARH 160012,INDIA

来源：

CANCER LETTERS | 1990年 / 55卷 / 02期

关键词：

VITAMIN-A DEFICIENCY; CIGARETTE SMOKE; LUNG TUMORS; BENZO[A]PYRENE;

D O I：

10.1016/0304-3835(90)90015-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vitamin A deficiency caused a significant increase (P < 0.05) in benzo[a]pyrene (BP)-induced lung tumor incidence and tumor burden in male Wistar rats. Inhalation of cigarette smoke during initiation and post-initiation phases of carcinogenesis resulted in higher tumor burden as compared to the same observed in the animals exposed to cigarette smoke during the post-initiation phase only. Stimulation in tumor burden by cigarette smoke was increased further by vitamin A deficiency.

引用

页码：83 / 88

页数：6

共 13 条

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