RESTORATION BY PIROXICAM OF LIVER GLUTATHIONE LEVELS DECREASED BY ACUTE ETHANOL INTOXICATION

被引：8

作者：

DEPINA, MZ ^{[1
]}

CORONA, S ^{[1
]}

ROCHAHERNANDEZ, AE ^{[1
]}

BALMORI, YS ^{[1
]}

CABRERA, G ^{[1
]}

PINA, E ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO, FAC MED VET & ZOOTECN, DEPT PROD ANIM AVES, MEXICO CITY 04510, DF, MEXICO

来源：

LIFE SCIENCES | 1994年 / 54卷 / 19期

关键词：

PIROXICAM; ETHANOL; ALCOHOL INTOXICATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GLUTATHIONE;

D O I：

10.1016/0024-3205(94)00598-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of piroxicam, a nonsteroidal anti-inflammatory drug, on blood ethanol and on triacylglycerols, malondialdehyde and glutathione levels in liver of fed rats acutely intoxicated with ethanol was studied. As previously reported for fasted rats, piroxicam in fed rats decreases the concentration of ethanol in blood and inhibits the hepatic increase of triacylglycerols and malondialdehyde consequent to ethanol administration. In addition, the hepatic depletion of reduced and reduced plus oxidized glutathione observed 8 and 12h after gavage of ethanol was reversed when piroxicam was administered simultaneously with ethanol. The importance of the finding is discussed in light of the paramount participation of glutathione during the cellular oxidative stress.

引用

页码：1433 / 1439

页数：7

共 23 条

[1] Akerboom T P, 1981, Methods Enzymol, V77, P373
[2] Bernt E, 1974, METHOD ENZYMAT AN, V3, P1499
[3] COMMENT CONCERNING A FLUOROMETRIC ASSAY FOR GLUTATHIONE
BEUTLER, E
WEST, C
[J]. ANALYTICAL BIOCHEMISTRY, 1977, 81 (02) : 458 - 460
[4] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5] BIOCHEMICAL ETHANOL EFFECTS AFFECTED BY A NONSTEROIDAL ANTIINFLAMMATORY DRUG
DEPINA, MZ
HERNANDEZTOBIAS, A
SALDANABALMORI, Y
DIAZBELMONT, A
PINA, E
[J]. FEBS LETTERS, 1992, 298 (2-3) : 123 - 125
[6] DEPINA MZ, 1993, ALCOHOL CLIN EXP RES, V17
[7] GOTTFFRIED SP, 1973, CLIN CHEM, V9, P1077
[8] GUNTHERBERG H, 1968, ACTA BIOL MED GER, V20, P559
[9] THE MEASUREMENT AND MECHANISM OF LIPID-PEROXIDATION IN BIOLOGICAL-SYSTEMS
GUTTERIDGE, JMC
HALLIWELL, B
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (04) : 129 - 135
[10] INSEL PA, 1990, GOODMAN GILMANS PHAR

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