A CLINICAL PHARMACOLOGICAL ASSESSMENT OF DOXAZOSIN AND ENALAPRIL IN COMBINATION

被引:7
作者
BAINBRIDGE, AD
MEREDITH, PA
ELLIOTT, HL
机构
[1] WESTERN INFIRM & ASSOCIATED HOSP,GARDINER INST,DEPT MED & THERAPEUT,GLASGOW G11 6NT,SCOTLAND
[2] CHARING CROSS & WESTMINSTER MED SCH,ACAD UNIT,LONDON,ENGLAND
[3] CHARING CROSS & WESTMINSTER MED SCH,DEPT CARE ELDERLY,LONDON,ENGLAND
关键词
DOXAZOSIN; ENALAPRIL; INTERACTION;
D O I
10.1111/j.1365-2125.1993.tb00421.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study in 12 normotensive males investigated potential pharmacokinetic and pharmacodynamic interaction mechanisms resulting from the combination of enalapril and doxazosin. Blood pressure reductions were consistently greater with the combination but there was no evidence of a significant pharmacodynamic interaction (as determined by heart rate changes, renal function tests or by pressor responsiveness indices) and there was not evidence of a pharmacokinetic interaction with either drug. Responsiveness to each drug i.e. blood pressure reduction per unit drug concentration was not significantly altered in the combination regimen. In conclusion, these results suggest that the combination of enalapril and doxazosin produces a usefully additive hypotensive effect but there was no evidence of synergism i.e an effect which was more than additive.
引用
收藏
页码:599 / 602
页数:4
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