A NOVEL GENE FAMILY ENCODING PROTEINS WITH HIGHLY DIFFERING STRUCTURE BECAUSE OF A RAPIDLY EVOLVING EXON

被引：44

作者：

LUNDWALL, A

LAZURE, C

机构：

[1] Department of Clinical Chemistry, Lund University, Malmö University Hospital

来源：

FEBS LETTERS | 1995年 / 374卷 / 01期

关键词：

SEMEN; PROTEIN; RAPID; EXON; GENE; EVOLUTION;

D O I：

10.1016/0014-5793(95)01076-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV: SVSV and guinea pig GP1 and GP2 belong to this gene family.

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页码：53 / 56

页数：4

相关论文

共 15 条

[1] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[2] ANDROGENS AFFECT THE PROCESSING OF SECRETORY PROTEIN PRECURSORS IN THE GUINEA-PIG SEMINAL-VESICLE .2. IDENTIFICATION OF CONSERVED SITES FOR PROTEIN PROCESSING [J].

HAGSTROM, JE ;

HARVEY, S ;

MADDEN, B ;

MCCORMICK, D ;

WIEBEN, ED .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (11) :1797-1806

[3]

HARRIS SE, 1990, J BIOL CHEM, V265, P9896

[4] SEMINAL-VESICLE SECRETION-IV GENE - ALLELIC DIFFERENCE DUE TO A SERIES OF 20-BASE-PAIR DIRECT TANDEM REPEATS WITHIN AN INTRON [J].

HARRIS, SE ;

MANSSON, PE ;

TULLY, DB ;

BURKHART, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (21) :6460-6464

[5] ANDROGEN-DEPENDENT SYNTHESIS OF BASIC SECRETORY PROTEINS BY RAT SEMINAL-VESICLE [J].

HIGGINS, SJ ;

BURCHELL, JM ;

MAINWARING, WIP .

BIOCHEMICAL JOURNAL, 1976, 158 (02) :271-282

[6] CLONING OF CDNA CODING FOR THE BETA-CHAIN OF HUMAN-COMPLEMENT COMPONENT C4B-BINDING PROTEIN - SEQUENCE HOMOLOGY WITH THE ALPHA-CHAIN [J].

HILLARP, A ;

DAHLBACK, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) :1183-1187

[7] MOLECULAR-CLONING OF EPIDIDYMAL AND SEMINAL VESICULAR TRANSCRIPTS ENCODING A SEMENOGELIN-RELATED PROTEIN [J].

LILJA, H ;

LUNDWALL, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4559-4563

[8] LIQUEFACTION OF COAGULATED HUMAN-SEMEN [J].

LILJA, H ;

LAURELL, CB .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1984, 44 (05) :447-452

[9]

LILJA H, 1989, J BIOL CHEM, V264, P1894

[10] BASIC PROTEIN RESPONSIBLE FOR CLOTTING OF GUINEA PIG SEMAN [J].

NOTIDES, AC ;

WILLIAMS.HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (05) :1991-&