PHARMACOKINETIC MODEL FOR DIAZEPAM AND ITS MAJOR METABOLITE DESMETHYLDIAZEPAM FOLLOWING DIAZEPAM ADMINISTRATION

被引:21
作者
JACK, ML [1 ]
COLBURN, WA [1 ]
机构
[1] HOFFMANN LA ROCHE INC,DEPT PHARMACOKINET & BIOPHARMACEUT,NUTLEY,NJ 07110
关键词
D O I
10.1002/jps.2600721120
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1318 / 1323
页数:6
相关论文
共 24 条
  • [1] CHANGES IN ORAL ABSORPTION CHARACTERISTICS IN MAN OF DIPOTASSIUM CLORAZEPATE AT NORMAL AND ELEVATED GASTRIC PH
    ABRUZZO, CW
    MACASIEB, T
    WEINFELD, R
    RIDER, JA
    KAPLAN, SA
    [J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (04): : 377 - 390
  • [2] COMPARATIVE PROTEIN-BINDING OF DIAZEPAM AND DESMETHYLDIAZEPAM
    ALLEN, MD
    GREENBLATT, DJ
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 20 (11-1) : 639 - 643
  • [3] CONTROLLED-STUDY OF DIAZEPAM IN PSYCHIATRIC OUTPATIENTS
    BEERMAN, HM
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1964, 120 (09) : 870 - &
  • [4] DETERMINATION OF CHLORAZEPATE AND ITS MAJOR METABOLITES IN BLOOD AND URINE BY ELECTRON-CAPTURE GAS-LIQUID-CHROMATOGRAPHY
    BROOKS, MA
    HACKMAN, MR
    WEINFELD, RE
    MACASIEB, T
    [J]. JOURNAL OF CHROMATOGRAPHY, 1977, 135 (01): : 123 - 131
  • [5] STEADY-STATE BIOAVAILABILITY OF 2 CLORAZEPATE DIPOTASSIUM DOSAGE FORMS
    CARRIGAN, PJ
    CHAO, GC
    BARKER, WM
    HOFFMAN, DJ
    CHUN, AHC
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 17 (01) : 18 - 28
  • [6] CHUN AHC, 1977, CLIN PHARMACOL THER, V22, P329
  • [7] COTLER S, J PHARM SCI
  • [8] EFFECTS AND PLASMA-LEVELS OF N-DESMETHYLDIAZEPAM AFTER ORAL-ADMINISTRATION IN NORMAL VOLUNTEERS
    DASBERG, HH
    [J]. PSYCHOPHARMACOLOGIA, 1975, 43 (02): : 191 - 198
  • [9] De Silva J A, 1970, Anal Chem, V42, P1725, DOI 10.1021/ac50160a040
  • [10] DIAZEPAM, A NEW TRANQUILIZER
    DIFRANCESCO, A
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1963, 119 (10) : 989 - &