SELECTIVE REDUCTION OF ALKYNES TO CIS-ALKENES BY HYDROMETALLATION USING [(PH3P)CUH]6

被引：73

作者：

DAEUBLE, JF ^{[1
]}

MCGETTIGAN, C ^{[1
]}

STRYKER, JM ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)97371-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective reduction of alkynes to the corresponding alkenes is reported using the stable, readily prepared copper(I) hydride reagent, [(Ph3P)CuH]6. Terminal alkynes are reduced at room temperature, unactivated internal alkynes react only at elevated temperature. Disubstituted alkynes with propargyl activation are also reduced, giving cis-olefins selectively. Protection of propargylic alcohol functionality is usually unnecessary, although fragmentation is sometimes competitive in sterically hindered cases. A tertiary propargyl acetate gave displacement to the allene exclusively. © 1990.

引用

页码：2397 / 2400

页数：4

共 19 条

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