ARACHIDONIC-ACID AND PROSTAGLANDINS ENHANCE POTASSIUM-STIMULATED CALCIUM INFLUX INTO RAT-BRAIN SYNAPTOSOMES

被引：15

作者：

KANDASAMY, SB

HUNT, WA

机构：

[1] Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda

来源：

NEUROPHARMACOLOGY | 1990年 / 29卷 / 09期

关键词：

arachidonic acid; brain; calcium; prostaglandins; synaptosomes;

D O I：

10.1016/0028-3908(90)90156-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Exogenous administration of arachidonic acid, prostaglandins PGF2α, PGD2 and PGE2 increased potassium-stimulated uptake of calcium in rat brain synaptosomes from the brain of the rat, but had no effect on the basal uptake of calcium. Arachidonic acid-induced uptake of calcium was mediated by its prostaglandin metabolites, because a cylooxygenase inhibitor, indomethacin, inhibited the response. l-Type calcium channel blockers, such as verapamil, diltiazem and nimodipine, blocked both KCl- and prostaglandin-enhanced potassium-stimulated influx of calcium in the brain. These results suggest that prostaglandins act as a calcium ionophore, through l-type voltage-sensitive calcium channels. © 1990.

引用

页码：825 / 829

页数：5

共 41 条

[1]

IDENTIFICATION OF PROSTAGLANDIN D2 AS A MAJOR PROSTAGLANDIN IN HOMOGENATES OF RAT-BRAIN [J].