THE EFFECT OF DEUTERIUM LABELING ON THE GENOTOXICITY OF N-NITROSODIMETHYLAMINE, EPICHLOROHYDRIN AND DIMETHYL SULFATE

被引：3

作者：

SARGENT, EV

KRAYNAK, AR

STORER, RD

BRADLEY, MO

PERRY, RM

机构：

[1] MERCK INST THERAPEUT RES,W POINT,PA 19486

[2] MERCK FROSST CANADA INC,MSD ISOTOPES,DORVAL H9R 4PJ,QUEBEC,CANADA

来源：

MUTATION RESEARCH | 1991年 / 263卷 / 01期

关键词：

DEUTERIUM; N-NITROSODIMETHYLAMINE; EPICHLOROHYDRIN; DIMETHYL SULFATE;

D O I：

10.1016/0165-7992(91)90027-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Deuterated and non-deuterated N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate were evaluated for the ability to induce DNA single-strand breaks in rat hepatocytes as measured by alkaline elution. Non-deuterated nitrosodimethylamine induced twice the amount of DNA-strand breaks as the deuterated form. No evidence of a deuterium isotope effect was seen for the direct-acting alkylating agents epichlorohydrin and dimethyl sulfate.

引用

收藏

页码：9 / 12

页数：4

相关论文

共 17 条

[1] MUTAGENICITY AND IRREVERSIBLE BINDING OF THE HEPATOCARCINOGEN, 2,4-DIAMINOTOLUENE [J].

AUNE, T ;

NELSON, SD ;

DYBING, E .

CHEMICO-BIOLOGICAL INTERACTIONS, 1979, 25 (01) :23-33

[2]

BONNEY RJ, 1974, IN VITRO CELL DEV B, V9, P399

[3]

BRADLEY MO, 1983, HDB MUTAGENICITY TES

[4] ENHANCEMENT OF CARCINOGENICITY OF 7,12-DIMETHYLBENZ[A]ANTHRACENE THROUGH REPLACEMENT OF HYDROGEN BY DEUTERIUM - NEW BIOLOGICAL ISOTOPE EFFECT [J].

BUUHOI, NP ;

GIAO, NB .

NATURWISSENSCHAFTEN, 1971, 58 (07) :371-&

[5] ISOTOPE-EFFECT ON CARCINOGENICITY OF 3-METHYLCHOLANTHRENE IN MOUSE SKIN BY SELECTIVE DEUTERATION OF 1-METHYLENE GROUP - BIOLOGICAL EVIDENCE FOR A MECHANISM OF TUMOR INITIATION [J].

CAVALIERI, E ;

GARCIA, H ;

MAILANDER, P ;

PATIL, K .

CHEMICO-BIOLOGICAL INTERACTIONS, 1975, 11 (03) :179-189

[6] DEUTERIUM-ISOTOPE EFFECT IN MICROSOMAL METABOLISM OF DIMETHYLNITROSAMINE [J].

DAGANI, D ;

ARCHER, MC .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1976, 57 (04) :955-957

[7] COMPARISON OF ALKYLATION RATES AND MUTAGENICITY OF DIRECTLY ACTING INDUSTRIAL AND LABORATORY CHEMICALS - EPOXIDES, GLYCIDYL ETHERS, METHYLATING AND ETHYLATING AGENTS, HALOGENATED HYDROCARBONS, HYDRAZINE DERIVATIVES, ALDEHYDES, THIURAM AND DITHIOCARBAMATE DERIVATIVES [J].

HEMMINKI, K ;

FALCK, K ;

VAINIO, H .

ARCHIVES OF TOXICOLOGY, 1980, 46 (3-4) :277-285

[8] DIFFERENT MECHANISMS ARE INVOLVED IN DNA DAMAGE, BACTERIAL MUTAGENICITY AND CYTO-TOXICITY INDUCED BY 1,2-DIBROMO-3-CHLOROPROPANE IN SUSPENSIONS OF RAT-LIVER CELLS [J].

HOLME, JA ;

SODERLUND, EJ ;

BRUNBORG, G ;

OMICHINSKI, JG ;

BEKKEDAL, K ;

TRYGG, B ;

NELSON, SD ;

DYBING, E .

CARCINOGENESIS, 1989, 10 (01) :49-54

[9] DEUTERIUM-ISOTOPE EFFECT ON CARCINOGENICITY OF DIMETHYLNITROSAMINE IN RAT-LIVER [J].

KEEFER, LK ;

LIJINSKY, W ;

GARCIA, H .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (01) :299-302

[10] THE EFFECT OF DEUTERIUM LABELING ON THE CARCINOGENICITY OF NITROSO-2,6-DIMETHYLMORPHOLINE IN RATS [J].

LIJINSKY, W ;

SAAVEDRA, JE ;

REUBER, MD ;

BLACKWELL, BN .

CANCER LETTERS, 1980, 10 (04) :325-331