CYCLOSPORINE INHIBITS RENAL URIC-ACID TRANSPORT IN RENAL-TRANSPLANTS NOT IN CHILDREN TREATED FOR NEPHROTIC SYNDROME

被引：5

作者：

STEIDEL, K ^{[1
]}

BRANDIS, M ^{[1
]}

KRAMER, M ^{[1
]}

LEITITIS, JU ^{[1
]}

ZIMMERHACKL, LB ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT PEDIAT,MATHILDENSTR 1,W-7800 FREIBURG,GERMANY

来源：

RENAL FAILURE | 1990年 / 12卷 / 03期

关键词：

D O I：

10.3109/08860229009065563

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Children with various grades of renal insufficiency (CON group) maintained uric acid excretion over a range of glomerular filtration rate (GFR) from 27 to 160 ml/min*l. 73m2 despite a decreased filtered load which was paralleled by glomerular filtration of uric acid. This was achieved by a compensatory decrease of net uric acid reabsorption (Tua) and an increasing fractional excretion of uric acid (FEua) with decreasing GFR. Although there was a decreased GFR in the group of children after transplantation (NTx group) there was no difference in Tua and FEua between the NTx group and the CON group. Uric acid transport was not affected in children treated with Cyclosporine (CyA)for nephrotic syndrome (NEPH group) compared to the CON group. Decreased fractional phosphate reabsorption in the NTx group suggests proximal tubule damage associatedwith disturbed uric acid handling. Under conditions of water diuresis hyperuricemia seen in NTx may result from an indirect effect of renal ischemic damage due to the transplantation procedure causing disturbance of proximal tubular uric acid (active) secretionlreabsorption. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：193 / 198

页数：6

共 11 条

[1]

Hoyer P., Lee I., Oemar B., Krohn H., Offner G., Brodehl J., Renal handling of uric acid under cyclosporin A treatment, Pediatr Nephrol, 2, pp. 18-21, (1988)

[2]

Zimmerhackl L.B., Fretschner M., Steinhausen M., Cyclosporin reduces renal blood flow through vasoconstriction of arcuate arteries in the hydronephrotic rat model, Klinische Wochenschr, (1990)

[3]

Weinman E., Eknoyan G., Suki W., The influence of the extracellular fluid volume on the tubular reabsorption of uric acid, J Clin Liv, 55, pp. 283-291, (1975)

[4]

Grantham J., Chonko A., Metabolism and Excretion of Uric acid, The Kidney, pp. 663-700, (1986)

[5]

Zimmerhackl L.B., Steidel K., Kuster P., Kramer M., Burghard R., Leititis J.U., Brandis M., Renal-tubulärer Transport von Hamsäure bei Nierenfunktionsstörungen, Monatsschr Kinderheilkunde, 135, (1987)

[6]

Zimmerhackl L.B., Kramer M., Blum S., Kuster P., Rausch P., Steidel K., Brandis M., Quantitative Bestimmung organischer Säuren in Plasma und Urin mit Hilfe der Ion-Exchange HPLC, Chromatographia, 22, (1986)

[7]

Steidel K., Renal tubulärer Transport von Harnsäure bei Kindern, (1989)

[8]

Roch-Ramel F., Diezi-Chomety F., Roth L., Weinerl, A Micropuncture Study of Urate Excretion by Cebus Monkeys Employing High Performance Liquid Chromatography with Amperometric Detection of Urate, Pflügers Arch, 383, pp. 203-207, (1985)

[9]

Staplelon B., Linshaw M., Hassanein K., Gruskin A., Uric acid excretion in normal children, J Pediatrics, 92, pp. 911-914, (1978)

[10]

Zimmerhackl L.B., Weber G., Hofer D., Fabricius T., Scott D.M., Brandis M., Drenckhahn D., Kinne R., New micromolecular markers of ne-phrotoxicity: Villin and Tamm-Horsfall-Protein as indicator of regional tubular regeneration/damage after renal transplantation, (1990)

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